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Although these caspases do not directly activate IL-1β and IL-18, they can induce potassium efflux through non-selective pores on the membrane, thereby activating the NLRP3 inflammasome and up-regulating caspase-1, which indirectly activates the classical regulatory pathway of pyroptosis [112, 113]

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10.1038/s41584-023-01006-3 28 ShaoD.LiM.WangZ.ZhengX.LaoY.-H.ChangZ.et al (2018)